Pluto Bioinformatics

GSE65955: Tet1 is a tumor suppressor of hematopoietic maligancy [RNA-Seq]

Bulk RNA sequencing

Loss of Tet1 expression causes global 5mC and 5hmC changes in stem and progenitor cells in mice and enhanced pro-B cell self-renewal, increased DNA damage and B-lymphomageneis. In this study we performed whole transciptome analysis using RNA-sequencing in purified long-term HSCs and MPPs. These results revealed that genes regulated byTet1 included Histones, DNA repair enzymes and B-lineage specific factors. SOURCE: Luisa Cimmino (luisa.cimmino@nyumc.org) - NYU