Pluto Bioinformatics

GSE84375: Salmonella Typhimurium evades macrophage defense by derailing metabolic pathways

Bulk RNA sequencing

In this study, we have employed RNA seq analysis to comprehensively understand the genes regulated in macrophages upon S.Typhimurium infection. Our data reveal that S. Typhimurium abrogates key metabolic pathways and their modulators. Disruption in metabolism leads to reduced acidification of phagosomes resulting in impaired bacterial clearance and antigen presentation. SOURCE: Nirmal Robinson (nirmal.robinson@uk-koeln.de) - Head of AG Robinson CECAD Forschungszentrum