Following all types of neurological injury, resident macrophages are activated locally, and blood-derived macrophages are recruited. Distinguishing the role of resident and blood-derived macrophages is complicated by the difficulty in distinguishing between these cell types because they mostly express the same molecular markers in a diseased state. To begin to understand the complexity of functions of resident and blood-derived macrophages following acute injury in the central nervous system (CNS) we ablated microglia, but not infiltrating macrophages, to determine their contribution following lysolecithin-induced demyelination . SOURCE: Jeff Biernaskie (jabierna@ucalgary.ca) - Biernaskie Lab University of Calgary

Pluto Bioinformatics

GSE121484: Transcriptional profiling of 5 days post LPC lesion after microglia ablation