Pluto Bioinformatics

GSE149136: Single cell RNA sequencing of CD42+ and CD42- iHPC in RUNX1 haploinsufficiency

Bulk RNA sequencing

To gain insights into the global and local transcriptomic changes underlying defective production of CD42a+ iHPCs in RUNX1+/-, we performed scRNA SEQ on sorted CD42a- and CD42a+ iHPCs from L1 and L1-C. There were on average 11,328 reads per cell with an average of 2,081 genes expressed. To identify and analyze distinct subpopulations in the control and RUNX1+/- iHPCs, dimension reduction was performed and cell clustering was visualized using uniform manifold approximation and projection (UMAP) SOURCE: Brian Estevez (estevezb@email.chop.edu) - Mortimer Poncz Children's Hospital of Philadelphia