In this study we applied RNA high-throughput seqencing to compare the global gene expression of young adult and aged iNKT subset in thymus of BALB/c mice.;	We found that only a small number of genes exerted a profound and statistically significant up- or downregulation upon ageing whereas a plethora of minor changes in the gene expression pattern were evident. However, significant age-related differences in expression of a variety of genes such as Histone genes, Gzma, CD25 and others might;	correlate with functional adaptations to the drastically altering thmyus micro-environment during aging. SOURCE: Günter Bernhardt (bernhardt.guenter@mh-hannover.de) -  Hannover Medical School

Pluto Bioinformatics

GSE147666: Identification of genes showing an age related expression in iNKT1, 2, and 17 cells of BALB/c thymus