Epithelial-to-mesenchymal transitions (EMT) play prominent roles during development, regeneration and tumor progression. EMTs are triggered by TGF-, RAS and other signals that cooperatively induce the expression of master EMT transcription factors such as SNAIL. Here, we elucidate how the TGF- and RAS pathways jointly trigger EMTs and tie them to broader developmental programs. We identify RAS response element binding protein 1 (RREB1) as a critical partner of TGF--activated SMAD transcription factors in driving SNAIL expression and EMT program in mammary gland epithelial cells. SOURCE: Jie Su Memorial Sloan Kettering Cancer Center

Pluto Bioinformatics

GSE128958: TGF- and RREB1 coordinate EMT programs in NMuMG cells