Pluto Bioinformatics

GSE120715: Quantitative analysis of bi-modal binding of BET proteins at promoters predicts I-BET sensitivity

Bulk RNA sequencing

We identified a chromatin displacement signature for the bromodomain proteins BRD2, BRD3 and BRD4 at TSS following treatment with I-BET152, an inhibitor of BET proteins. By integrating ChIP-seq, RNA-seq and Chem-seq data, we correlated alteration of the BRD4 signature at TSS with strong downregulation of gene expression which will facilitate identification of markers of sensitivity and resistance to drug. SOURCE: Pierre Khoueiry American University of Beirut