Pluto Bioinformatics

GSE118751: A Functional Role for REST Co-Repressor 2 (Rcor2) in Callosal Development

Bulk RNA sequencing

Pallial functional organization is mediated by the dynamic interplay of a broad spectrum of cellular and molecular cues that promote midline patterning, neurogenesis, axon guidance and neural connectivity. The regulators that orchestrate these seminal processes are still poorly understood. By employing a pallial conditional ablation model, we report that the transcriptional and epigenetic modulator, REST corepressor 2 (Rcor2) plays key roles in organizing the developing corticoseptal boundary. ChIP-seq and RNA-seq analyses reveal that Rcor2 modulates a diverse repertoire of classes of genes with essential roles in CC development, including pallial/subpallial patterning, cell fate specification and axon guidance. SOURCE: Mark,F,Mehler (mark.mehler@einstein.yu.edu) - Mehler Albert Einstein College of Medicine