Pluto Bioinformatics

GSE76097: In vivo analysis of astrocyte ribosome-associated mRNA after traumatic spinal cord injury

Bulk RNA sequencing

Analysis of gene expression by astrocytes or non-astrocyte cells in spinal cord injury (SCI) lesions may lead to the identification of molecules that impact on axon regrowth. We conducted genome-wide RNA sequencing of (i) immunoprecipitated astrocyte-specific ribosome-associated RNA (ramRNA) from WT or STAT3-CKO astrocytes, and (ii) the non-precipitated (flow-through) RNA deriving from non-astrocyte cells in the same tissue samples 14 days following SCI.; DOI: 10.1038/nature17623 SOURCE: Riki Kawaguchi (rkawaguchi@mednet.ucla.edu) - Giovanni Coppola University of California Los Angeles