Pluto Bioinformatics

GSE95251: Genomic responses of mouse synovial fibroblasts during TNF-driven arthritogenesis greatly mimic those of human rheumatoid arthritis (RNA-Seq).

Bulk RNA sequencing

We used deep sequencing to probe the transcriptome, the methylome and the chromatin landscape of cultured mouse arthritogenic SFs at three stages of disease, as well as SFs stimulated with human TNF. We performed bioinformatics analyses at the gene, pathway and network levels, compared mouse and human data, and validated selected genes in both species. SOURCE: Panagiotis Chouvardas (chouvardas@fleming.gr) - BSRC "Alexander Fleming"/National and Kapodistrian University of Athens