We sequenced the transcriptomes of seven samples of hypothalamic neurons dervied from pluripotent stem cells taken from healthy patients; five samples of hypothalamic neurons derived from pluripotent stem cells of constitutionally obese donors; five samples of sectioned hypothalami from post-mortem dissection of brains, and two samples for motor neurons derived from pluripotent stem cells of healthy donors in order to assess the similarity of our iPSC-derived cells against those of sectioned brains and to identify possible transcriptional disfunction which might underlie extreme, inherited obesity. SOURCE: Dhruv Sareen (dhruv.sareen@cshs.org) - Sareen lab Cedars-Sinai Medical Center

Pluto Bioinformatics

GSE95243: Transcriptomes of iPSC-derived and post-mortum Hypothalamus Neurons from obese and control donors