Pluto Bioinformatics

GSE64824: Hepatic transcriptome profiling of liver-specific Xbp1 knockout mice fed a high fat diet

Bulk RNA sequencing

Xbp1 is an important regulator of unfolded protein response and lipid metabolism. Its dyregulation has been associcated in human NASH. Feeding a high fat diet with fructose/sucrose to mice causes progressive, fibrosing steatohepatitis. This study is to use RNA-Seq to identify differentially expressed genes in hepatic Xbp1 deficient mice livers fed with a high fat diet compared to controls. SOURCE: Richard Green (r-green2@northwestern.edu) - Northwestern University