Pluto Bioinformatics

GSE138729 (mouse): Induction of extracellular adenosine salvage and metabolic quiescence regulate the transitional to follicular B cell checkpoint in humans.

Bulk RNA sequencing

Transcriptional profiling of transitional and follicular B cells showed that metabolic quiescence was acquired at the follicular B cell stage in both humans and mice, characterized by an orchestrated reduction of mTORC1 signaling, aerobic respiration and expression of genes involved in ribosome biogenesis. SOURCE: Vinay Mahajan Ragon Institute of MGH, MIT and Harvard