Pluto Bioinformatics

GSE76095: CFTR is a tumor suppressor gene in murine and human intestinal cancer [RNA-seq]

Bulk RNA sequencing

Analysis of the cystic fibrosis gene Cftr in the colon and small intestine of Cftr-deficient murine model. The hypothesis was loss of Cftr altered expression of genes important in intestinal homeostasis and oncogenic signaling pathways. The results identified potential roles of Cftr in up- or down-regulating major gene clusters that belong to groups of immune response, ion channel, intestinal stem cell and other growth regulators. SOURCE: Ying Zhang (yingzhang@umn.edu) - University of Minnesota