Phf8 is a histone demethylase with links to human behavior. Here we have performed a transcriptional analysis of Phf8 knockout embryonic stem and neural projenitor cells in vitro along with an analysis of the prefrontal cortex and ventral striatum in vivo. Our results suggest that knockout of Phf8 is largely compensated for. However, we did observe a misregulation of serotonin receptors in the prefrontal cortex, which may have disease implications. SOURCE: Ryan Walsh (walshr1@mskcc.org) - Hochedlinger Harvard

Pluto Bioinformatics

GSE90019: Analysis of transcriptional and epigentic changes induced by loss of Phf8 [RNA-seq]