Here we show that the T-box transcription factor encoded by Tbx1 positively regulates monomethylation of histone 3 lysine 4 (H3K4me1) at a significant number of regions that it occupies throughout the genome, often located at the 3' end of target genes. Treatment of cells with Tranylcypromine (TCP), an inhibitor of histone demethylases, rescues the expression of approx. one third of the genes dysregulated by Tbx1 suppression and it rebalances H3K4me1 levels at many Tbx1 occupied sites. In addition, TCP treatment of mouse models of the 22q11.2DS ameliorates substantially the cardiovascular phenotype. SOURCE: Antonio Baldini (antonio.baldini@igb.cnr.it) -  CNR Institute of Genetics and Biophysics Adriano Buzzati Traverso

Pluto Bioinformatics

GSE79941: Rebalancing gene haploinsufficiency in vivo by targeting chromatin