Pluto Bioinformatics

GSE70831: MiR-26 dampens IL-6 production by down-regulating TNF-a/NF-kB signaling through silencing HMGA1 and MALT1 and not by directly targeting IL-6 mRNA

Bulk RNA sequencing

We found NF-kB signaling as a major target of miR-26 based on an analysis of the changes in gene activation by TNF-a in response to alteration of miR-26 levels. SOURCE: Jeffrey Chang (jeffrey.t.chang@uth.tmc.edu) - UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON