Pluto Bioinformatics

GSE115190: RNA-seq analysis of whole liver derived from endothelial specific TAK1 conditional knockout mice.

Bulk RNA sequencing

In this study we show that TGF-activated kinase 1 (TAK1), is crucial for ensuring EC survival on TNF stimulation. EC-specific TAK1-knockout in adult mice resulted in rapid death of the animal due to destruction of intestinal and liver blood vessels. TNF from myeloid cells responding to intestinal microbiota was responsible for EC death in the intestine and liver. Our results illuminate mechanisms ensuring survival of intestinal and liver EC under physiological conditions SOURCE: Jun-ichi Suehiro Kyorin University School of Medicine