Pluto Bioinformatics

GSE62642: RNA-Seq Analysis in purified iPS cell-derived neuronal samples

Bulk RNA sequencing

We characterized the gene expression differences in mDA neurons from all PD (Parkinson's disease) cases (6 independent samples) and controls (8 independent samples), identifying 1,028 differentially expressed genes making up the PD expression signature. Strikingly, MAOB gene was identified as significantly differentially expressed (p = 0.046). The heat map clearly differentiates cases from controls, where interestingly most differentially expressed genes had lower expression in PD cases compared to controls. In the clustering, the RNA expression pattern of the control (C2) with a family history of PD located close to the PD expression signature suggested a susceptibility to PD. SOURCE: Aiqun Li (leeaiqun@hotmail.com) - The New York Stem Cell Foundation