Pluto Bioinformatics

GSE73857: Newly constructed network models of different WNT signaling cascades applied to breast cancer expression data

Bulk RNA sequencing

RNA-Seq profiling of MCF-7 and MDA-MB-231.; We profiled RNA expression in the estrogen-receptor-positive (ER+) MCF-7 and the triple-negative MDA-MB-231 breast cancer cells.; The objective was to find genes differentially expressed between these cell lines as potential drivers of invasiveness of the triple-negative MDA-MB-231.; We further utilized the identified differential genes to validate expression-responsive module of non-canonical Wnt signaling pathway. SOURCE: Tim Beissbarth (tim.beissbarth@ams.med.uni-goettingen.de) - University Medical Center Göttingen