miR-34a and miR-34b/c genes are frequently epigenetically silenced in primary CRCs. However, the in vivo relevance of miR-34a/b/c for suppression of intestinal tumor formation has not been analyzed by genetic approaches. ApcMin/+ mice with deletion of the miR-34a and miR-34b/c genes were generated and analyzed. The mRNA expression profiles of intestinal adenomas with and without functional miR-34a/b/c genes were compared. SOURCE: Longchang Jiang (Longchang.Jiang@med.uni-muenchen.de) - Experimental and Molecular Pathology Ludwig-Maximilians-University München

Pluto Bioinformatics

GSE84138: miR-34a and miR-34b/c suppress intestinal tumorigenesis in ApcMin/+ Mice