Pluto Bioinformatics

GSE146315: Emergent metastatic heterogeneity of primary tumor cells is restricted by the Ig-transmembrane protein VSIG VI

Bulk RNA sequencing

Our study prompeted us to assign, through spiked single cell RNAseq, metastatic function to transcriptomic cluster of colon cancer cells. Interactions between clones also uncover a restrictive anti metastatic influence that act intrinsically and non-cell automomously. We identify VSIG1 as critical mediator of this influence. SOURCE: Celine Delucinge University of Geneva