Pluto Bioinformatics

GSE126217: RNAseq analysis of glomerular transcriptome of wild-type vs. Podocyte Cosmc knockout

Bulk RNA sequencing

Cosmc is an obligate chaperone for C1GalT1 T transferase necessary for generating mature mucin-type O-glycans. Animals lacking Cosmc in glomerular podocytes develop proteinuria, glomerulosclerosis and progressive renal failure. This study was designed to examine transcriptome differences in 1 month male animals with and without podocyte Cosmc, a time point when proteinuria is established but glomerular architecture is still relatively intact. SOURCE: Johannes Schlondorff (jschlond@bidmc.harvard.edu) - Beth Israel Deaconess Medical Center