Pluto Bioinformatics

GSE136345: mRNA expression in CD4+ T cells of malignant pleural effusion (MPE) from WT and IL-10 knock out mice

Bulk RNA sequencing

The interactions between tumor cells and the host vasculature and immune cells results in increased net fluid production via enhanced plasma extravasation into the pleural space.Understanding the regulatory mechanism of IL-10 in MPE formation is essential both for deciphering how IL-10 acts in regulating tumor immunity and for discovering key molecular targets for intervention in advanced cancers. SOURCE: Yuan Yang Beijing Chaoyang Hospital, Capital Medical University