Pluto Bioinformatics

GSE141503: RUNX transciption factor mediated control of breast cancer stem cells

Bulk RNA sequencing

Cancer stem cells (CSC) are postulated to be capable of initiating tumor formation, growth, and are resistant to therapies thereby causing tumor recurrence. We flow sorted breast cancer stem cells using CD24 (a negative marker) and CD44 (a positive marker) and performed RNAseq to determine what genes and pathways are altered in the CD24 low/ CD44 high subpopulation relative to CD24high/CD44+ subpopulation. SOURCE: Jonathan,R,Gordon (Jonathan.A.Gordon@med.uvm.edu) - University of Vermont