The purpose of this study was to define unique classes of EWS/FLI target genes and the distinct set of structural features present in the EWS domain required for target gene regulation at different EWS/FLI response elements. This study reports the first genome-wide transcriptomic description of a partially-functional EWS/FLI mutant . We report new structure-function dependencies across different classes of response element and tie these dependencies to the ability of EWS/FLI to transform cells. SOURCE: Emily,Rose,Theisen (emily.theisen@nationwidechildrens.org) -  Nationwide Children's Hospital

Pluto Bioinformatics

GSE122535: Transcriptomic analysis to functionally map the intrinsically disordered domain of EWS/FLI [Experiment 1]