Pluto Bioinformatics

GSE132703: mTORC1 controls a dynamic program of TOP mRNA translation via LARP1

Bulk RNA sequencing

LARP1 has been proposed to control the translation of TOP mRNAs downstrteam of mTORC1. Here we used ribosome profiling to analyze transcriptome-wide changes in translation following mTOR inhibition in wild-type HEK-293T cells and cells where LARP1 (sgLARP1) or LARP1 and its homologue LARP1B (sgLARP1/1B) have been deleted using CRISPR/Cas9. SOURCE: Carson,C,Thoreen (carson.thoreen@yale.edu) - Yale School of Medicine