Pluto Bioinformatics

GSE138704: RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1.

Bulk RNA sequencing

IGF2BP1 promotes leukemia stem cell phenotype by regulating HOXB4, MYB and ALDH1A1. Inhibition of IGF2BP1 reduces leukemia tumorigenicity, and enhances leukemia cell death and differentiation. SOURCE: Irina Elcheva (irina.elcheva@gmail.com) - C7848 PennState College of Medicine