The goal of this analysis was to investigate the targets of the influenza A host shutoff ribonuclease PA-X. We profiled the relative levels of cellular RNAs in cells infected with influenza A virus (A/PuertoRico/8/1934 H1N1) comparing wild-type and mutants that make reduced levels of PA-X and/or make a truncated and inactive PA-X. We also profiled relative RNA levels in cells overexpressing wild-type PA-X or a catalytically inactive mutant (D108A). SOURCE: Marta,Maria,Gaglia (mgaglia@gmail.com) -  Tufts University School of Medicine

Pluto Bioinformatics

GSE120183: Profiling of RNAs downregulated by influenza A virus PA-X ribonuclease