Pluto Bioinformatics

GSE146285: Single-cell transcriptomics during different phases post cardiac ischemia reveals secreted B2M to regulate fibroblast activation

Bulk RNA sequencing

The efficiency of the repair process following ischemic cardiac injury is a crucial determinant for the progression into heart failure and is controlled by both intra- and intercellular signaling within the heart. An enhanced understanding of this complex interplay will enable better exploitation of these mechanisms for therapeutic use. We used single-cell transcriptomics to collect gene expression data of all main cardiac cell types at different time-points after ischemic injury. SOURCE: Eva van Rooij ( - Hubrecht Institute

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