Pluto Bioinformatics

GSE75851: ILC progenitor CEL-seq

Bulk RNA sequencing

Here we identify the c-kit+ CILP population which generates all ILC subsets including NK cells, and the CD25- ILC2-restricted Sca-1+ CILP. We mapped the transcriptional changes that occur in ILC progenitor commitment identifying new regulatory factors and provide a map for early ILC differentiation. Finally, we mapped the subsequent transcriptional changes that occur in c-kit+ CILP in absence of Id2 and Tcf7, key regulators downstream of Nfil3. SOURCE: Shian Su (su.s@wehi.edu.au) - Ritchie Lab Walter and Eliza Hall Institute of Medical Research