Pluto Bioinformatics

GSE102277: Determination of Nir (Noc2l) function in epidermis during mouse development by global transcriptome analysis

Bulk RNA sequencing

To investigate the role of Nir in epidermis during embryogenesis, we crossed mice harboring conditional Nir alleles with the Krt14-Cre deleter strain, which results in Cre-mediated loss of Nir selectively in epidermis. Transciptome analysis of keratinocytes obtained from control and knock-out mice at E15.5 revealed 4393 genes differentially expressed between Nir knock-out and control mice (p-value<10-2). At E17.5, we found 5673 differentially expressed genes. SOURCE: Delphine Duteil (delphine.duteil@uniklinik-freiburg.de) - AG Schüle ZKF, Uniklinik