Pluto Bioinformatics

GSE98032: SiO2 Nanoparticles Modulate The Electrical Activity Of Neuroendocrine Cells Without Exerting Genomic Effects

Bulk RNA sequencing

Different electrophysiological approaches are combined with a genomic screening in order to analyze, in GT1-7 neuroendocrine cells, the impact of SiO2 nanoparticles (NPs; 503nm in diameter) on electrical activity and gene expression. It is found that 20 g mL-1 NPs induce depolarization of the membrane potential, with a modulation of the firing of action potentials. Recordings of electrical activity with Multielectrode Arrays provide further evidence that the NPs evoke a temporary increase in firing frequency, without affecting the functional behaviour on a longer time scale (hours). Finally, NPs incubation up to 24 h does not induce any change in gene expression SOURCE: Danny Incarnato (danny.incarnato@hugef-torino.org) - HuGeF