Preeclampsia (PE) is a multi-system disorder that is primarily characterised by new-onset hypertension accompanied by proteinuria during gestation. This disease affects 3-5% of all pregnancies and is one of the leading causes of maternal and perinatal morbidity and mortality. In this work, placental samples were collected from PE and control patients. RNA-seq was performed to identify differences in gene expression. Significantly differentially expressed genes between the PE and control samples included 68 up-regulated and 52 down-regulated genes. This study may provide further insight in the mechanisms of PE and function as preventive, predictive and therapeutic measures. SOURCE: Jin Wang (wangjinshiyi@126.com) -  Jinan Maternal and Child Health Care Hospital

Pluto Bioinformatics

GSE143953: RNA sequence of preeclampsia and healthy control placentas