Pluto Bioinformatics

GSE79758: Differential gene expression in intestinal mouse crypts after loss of KLF5

Bulk RNA sequencing

To determine potential targets of KLF5 we performed RNA-sequencing on jejunal crypts isolated from Klf5-deficient and wildtype mice, using three biological replicates per genotype. We identified 1,480 genes that showed significant differential expression with at least a 2-fold difference between Klf5-deficient and wildtype (q-value 0.05) (Figure 5A; Supplementary Table 1). Klf5 expression was significantly downregulated 2.7-fold. SOURCE: Noah,F,Shroyer (noah.shroyer@bcm.edu) - Baylor College of Medicine