Pluto Bioinformatics

GSE103261: RNAseq and ChIPseq on Mouse Embryonic Stem Cells and Sorted Mesendoderm Progenitor Cells [RNA-seq]

Bulk RNA sequencing

We mapped the enhancer and long non-coding transcriptional landscape during mesendoderm specification. Mesendodermal progenitors were sorted from differentiating ESCs according to Eomes expression. Enhancer usage was coordinated with mesendoderm-specific expression of key lineage-determining transcription factors. We demonstrated that many of these enhancers are associated with the expression of lncRNAs. SOURCE: Frederic Burdet (frederic.burdet@isb-sib.ch) - Swiss Institute of Bioinformatics