Pluto Bioinformatics

GSE151190: Disruption of WNT-LMX1A Regulatory Loop During Midbrain Dopaminergic Neuron Development in Human DNAJC6 Parkinson Disease Model

Bulk RNA sequencing

In this study, human isogenic model of juvenile onset PD caused by DNAJC6 mutation were made. Human ESCs edited using CRISPR-Cas9 to make deleterious DNAJC6 mutation was induced to human midbrain like organoid (hMLO) for studying the mechanism of DNAJC6 deleterious mutation in causing PD SOURCE: Wahyu,Handoko Wibowo,Darsono (wahyu_handoko@outlook.com) - Lee Sang-Hun Lab Hanyang University