We examined the transcriptional changes modulated by estrogen receptor beta (ER) by performing global transcriptome analysis. U87 cells were transduced with lentiviral particles carrying either empty vector or ER-FLAG expression vector and the RNA was isolated and utilized for RNA-seq analysis. Our results demonstrated that ER modulated genes were related to homologous recombination, DNA damage response, ATM signaling and cell cycle pathways. SOURCE: YI ZOU (zou@uthscsa.edu) -  UTHSA-GCCRI

Pluto Bioinformatics

GSE121332: Estrogen receptor beta enhances chemotherapy response of GBM cells by down regulating DNA damage response pathways