Pluto Bioinformatics

GSE129975: Atrx deletion in neurons leads to sexually-dimorphic dysregulation of miR-137 and spatial learning and memory deficits

Bulk RNA sequencing

Ablation of the ATRX chromatin remodeler specifically in forebrain excitatory neurons of mice causes male-specific deficits in long-term spatial memory associated with miR-137 overexpression, transcriptional changes and structural alterations corresponding to pre- and post-synaptic abnormalities. SOURCE: Vanessa Dumeaux (vanessadumeaux@gmail.com) - Concordia University