To examine the regulation of microglia by N-AS-triggered SPMs, we analyzed the gene expression patterns of microglia derived from WT, APP/PS1, and N-AS-injected APP/PS1 mice using RNAseq. These results indicated that N-AS-triggered SPMs activated an anti-inflammatory, positive immune response, and enhanced the phagocytic abilities of microglia in N-AS-treated APP/PS1 mice, leading to resolution of neuroinflammation and upregulation of phagocytic microglia in this AD animal model. SOURCE: Hee Kyung Jin (hkjin@knu.ac.kr) -  Kyungpook National University

Pluto Bioinformatics

GSE146133: Total RNA Sequencing in microglia isolated from N-AS treated APP/PS1 mice