Pluto Bioinformatics

GSE112398: Polycomb repressive complex 1 (PRC1) role in skin epithelium development [Epidermis I53A]

Bulk RNA sequencing

Polycomb repressive complexes (PRC) 1 and 2 are essential chromatin regulators of cell identity. PRC1, a dominant executer of Polycomb-mediated control, functions as multiple sub-complexes that possess catalytic-dependent H2AK119 mono-ubiquitination (H2AK119ub) and catalytic-independent activities. Here, we show that despite its well-established repressor functions, PRC1 binds to both silent and active genes. Through in vivo loss-of-function studies, we show that global PRC1 function is essential for skin development and stem cell (SC) specification. SOURCE: Dejian Zhao ( - Albert Einstein College of Medicine

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