RNA-sequencing demonstrated Acod1 (Aconitate decarboxylase 1) as one of the top genes induced by air polution particulate matter (PM) in macrophages. We therefore sought to determine the effect of both exogenous itaconate (4-octyl itaconate) and endogenous itaconate on PM-induced inflammation in macrophages through RNA sequencing. SOURCE: Yan Li (yli22@bsd.uchicago.edu) -  The University of Chicago

Pluto Bioinformatics

GSE143881: Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response