Pluto Bioinformatics

GSE113931: High-resolution comparative analysis of great ape genomes

Bulk RNA sequencing

We couple long-read sequence assembly, full-length cDNA sequencing, and a multi-platform scaffolding approach to produce ab initio chimpanzee and orangutan genome assemblies where most genes are complete, gaps are closed, and novel gene models are identified. We further analyzed the overlap between structural variants in the human genome and gene expression differences in human and chimpanzee cells, including iPS-derived organoid radial glia cells. SOURCE: Alex,Aaron,Pollen (alex.pollen@ucsf.edu) - Pollen UCSF