Resting NK cells are notoriously difficult to transduce, especially using the VSVG lentivirus pseudotype. When NK cells are expanded and activated using the NKAES system, there is a modest improvement of transduction rates compared to their resting NK counterparts. Still, the transduction efficiency remains poor for robust development of NK cell-based cancer immunotherapy. We envisaged to have a genome-wide expression profile of resting and activated NK (NKAES) cells in order to improve currrent transduction protocols . SOURCE: Panojot Bifsha (panojot.bifsha@gmail.com) -  CHU Sainte-Justine

Pluto Bioinformatics

GSE128696: Gene expression comparison of resting human peripheral-blood NK cells and activated counterparts