Pluto Bioinformatics

GSE102007: Gene expression profiling of murine skin transgenically generated to express HPV16 E7 oncoprotein

Bulk RNA sequencing

A validated animal model would assist with research on the immunological consequences of the chronic expression of HPV16 E7 oncoprotein expression. Here we performed RNA-seq analysis of normal C57BL/6 skin versus mouse transgenically generated to express HPV16 E7 oncogene under the keratin 14 promoter (K14E7). Mice present with epithelial hyperplasia and increased immune cell infiltrate associated with immune suppression. SOURCE: Zewen Kelvin Tuong (z.tuong@uq.edu.au) - The University of Queensland Diamantina Institute