Pluto Bioinformatics

GSE83243: Regionally distinct roles of ATXN1-CIC complex in ADHD and autism

Bulk RNA sequencing

We isolated RNAs from Otp-lineage cells in the mouse brain using translating ribosome affinity purification (TRAP) approach. We compared two groups of mice: Otp-cre; ROSAfsTRAP (control) and Otp-cre; Cicf/f; ROSAfsTRAP (conditional knockout). Following RNA isolation, RNAseq was performed and gene expression profiles were compared between controls and conditional knockouts. SOURCE: Qiumin Tan (qtan@bcm.edu) - Huda Zoghbi Baylor College of Medicine

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