Pluto Bioinformatics

GSE113855: Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury

Bulk RNA sequencing

Here we demonstrate that the neurovasculature exhibits a unique transcriptional signature following inflammatory insults, and pharmacological inhibition of monoacylglycerol lipase using a newly characterized inhibitor, rescues the transcriptional profile of brain vasculature, and restores its functional homeostasis. SOURCE: Jie Quan (jie.quan@pfizer.com) - Pfizer