Pluto Bioinformatics

GSE136216: EGR1 as gatekeeper of inflammatory enhancers during immune cell development

Bulk RNA sequencing

We investigated the function of EGR1 in macrophage differentiation and activation. We generated EGR1 CHIP-seq and CUT-and-RUN data during GM-CSF induced macrophage differentiation, paired with ATAC-seq. We performed RNA-seq and CHIP-seq for H3K27ac in EGR1-depleted differentiated macrophages. Finally we generated RNA-seq data in activated macrophages with EGR1 overexpression. SOURCE: Marco Trizzino (marco.trizzino83@gmail.com) - The Wistar Institute