Pluto Bioinformatics

GSE97696: Chemical Inhibition of Ezh2 Enhances Ex Vivo B cell Differentiation

Bulk RNA sequencing

To understand the role of Ezh2 in B cell differentiation B cells were stimulated ex vivo with LPS, Il2, and Il5 in the presence of DMSO or the selective Ezh2 inhibitor GSK343. Following 3 days culture, RNA-seq was performed to identify the molecular effects of Ezh2 inhibition on B cell differentiation. SOURCE: Chris Scharer (cdschar@emory.edu) - Jeremy Boss Emory University