This study explored the interaction of early life and adult stress on transcriptional and chromosomal states in a 2x2 design. Male mice were subjected to early life stress (ELS) or were standard-reared (Std), were housed normally through adolescence, and were then exposed to 10 days of control (Ctl) or chronic social defeat stress (CSDS) conditions in adulthood. Long-lasting transcriptional and chromatin alterations were assessed in the ventral tegmental area (VTA) of the midbrain in adulthood. SOURCE: Catherine,Jensen,Pena (cate.j.pena@gmail.com) - Nestler Icahn School of Medicine at Mount Sinai

Pluto Bioinformatics

GSE89692: Transcriptional response to early life stress in mouse ventral tegmental area